Formulating Buffered Dissolution Media for Sparingly Soluble Weak Acid and Weak Base Drug Compounds Based on Microenvironmental pHo Considerations
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چکیده
منابع مشابه
Formulating Buffered Dissolution Media for Sparingly Soluble Weak Acid and Weak Base Drug Compounds Based on Microenvironmental pHo Considerations
The theoretical framework for dissolution of weak acid and weak base drug compounds in buffered media is well established. Therefore, this article is intended to provide a review of this framework and apply it to formulate buffered dissolution media based on ionic equilibrium conditions within the diffusion layer at the solid–liquid interface. The pHo in the microenvironment is identified as a ...
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ژورنال
عنوان ژورنال: Dissolution Technologies
سال: 2014
ISSN: 1521-298X
DOI: 10.14227/dt210414p20